..
— simonthong aka kitty poo (@KittyPo80176717) December 31, 2021
https://t.co/U7Cj5NVdRP pic.twitter.com/dakI9ZOnoa
— simonthong aka kitty poo (@KittyPo80176717) December 31, 2021
..
CoronaVac is an inactivated SARS-CoV-2 vaccine approved for use in 48 countries. In collaboration with the Ministry of Health in Dominican Republic, we tested whether CoronaVac (2x) + Pfizer booster induces neutralizing Abs to Delta and Omicron. (1/) https://t.co/GWs9nyIwZV
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
Next, @carolilucas & @ValterVSM analyzed NAb against ancestral vs. Delta variant. CoronaVac 2x followed by Pfizer mRNA vax booster robustly elevated NAb against both virus types, level similar to 2x Pfizer vaccine. (3/) pic.twitter.com/7SFUVY5Q0G
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
In CoronaVac fully vaccinated (2x) people, there was NO detectable neutralization against the infectious Omicron virus. Antibodies were assayed at mean days from second Coronavac shot of 113 days (with SD 33 days). (5/) pic.twitter.com/Nx23wgrykH
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
How does prior infection modify neutralization against Omicron? In the mRNA vaccine recipients (28 days after second dose), prior infection provided advantages in cross protection against VOCs, including Omicron. (7/) pic.twitter.com/SPpg6dB51i
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
Immunologically, this difference is interesting. Prior infection only synergies with the mRNA vax to elevate broadly neutralizing Ab but not with inactivated vax. This may relate to the persistent GC responses in mRNA vax reported by @TheBcellArtist. (9/) https://t.co/6lcVDILO9L
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
Lots of amazing folks from Dominican Republic and Yale contributed to this work. Special thank you to @SVermund for orchestrating this collaboration, and Drs. Eddy Perez-Then and Marija Miric for their leadership in DR. Always fantastic @carolilucas @ValterVSM 👏🏼 👏🏼 (end) pic.twitter.com/ctEUPiKdgw
— Prof. Akiko Iwasaki (@VirusesImmunity) December 30, 2021
..
weehingthong 