2) How is the vaccine efficacy across age, gender, race, and country subgroups? Very similar! pic.twitter.com/e3UngmAOkh

— Eric Feigl-Ding (@DrEricDing) December 10, 2020

The BioNTech/Pfizer data is out—NEJM & FDA report. I understand this wasn't in the design & the long-term protection from single dose is open question. But given this sharp drop after 14 days after one dose, can someone explain why single dose isn't very very high on the agenda? pic.twitter.com/sxqwACGulz

— zeynep tufekci (@zeynep) December 10, 2020

Maybe. There are 1256 people who did not receive the second dose in the trial. Yes, small group but what happened to them? I get it, ideally, we have a single dose study. Not so ideally, we have this data and a severe shortage. Seems worth a discussion. https://t.co/5RyU1KwNDK

— zeynep tufekci (@zeynep) December 10, 2020

I'm hoping for immunology/virology people to tell us the potential trade-offs here. We know one side: due to shortages, hundreds of millions of people will not get vaccinated anytime soon. What does the calculation on the other side look like?

— zeynep tufekci (@zeynep) December 10, 2020

Yeah, but given the stakes, "we don't know for sure so we won't vaccinate hundreds of millions" is not an acceptable answer. Shortage is a terrible trade-off, too. Why didn't they/we immediately launch a single dose trial after prelim data? They knew. https://t.co/nwl0LmMIdl

— zeynep tufekci (@zeynep) December 10, 2020

This is immediately consequential. US plans to HOLD BACK for many millions now vaccination to preserve for second dose later. @ScottGottliebMD—Pfizer board member—disagrees: "We should get as many shots in our arms as possible right now." https://t.co/9S17hJF3WL pic.twitter.com/6CGpcLlsSb

— zeynep tufekci (@zeynep) December 10, 2020

Pfizer vaccine deaths: Related or unrelated to the vaccine itself?https://t.co/LF58vC72zM

— KittyPooh (@KittyPo80176717) December 9, 2020

VRBPAC will meet Dec 10th to discuss the Pfizer vaccine. Appendicitis, Bells palsy, heart attack and death were noted in this doc but dismissed as unrelated w/out pathological examination. Terms like "numerical imbalance" used to describe statistical diff.https://t.co/AVDkxSk1nI pic.twitter.com/32XgMczBmY

— Eileen Iorio (@eileeniorio) December 8, 2020

LATEST: Pfizer and BioNTech's vaccine is highly effective in preventing Covid-19 and safe, a report by staff of the FDA says https://t.co/wKaxFWRqyB

— Bloomberg (@business) December 8, 2020

“This is what an A+ report card looks like for a vaccine” — @VirusesImmunity https://t.co/Yiv1zyHRt3

— Carl Zimmer (@carlzimmer) December 8, 2020

BREAKING: FDA scientists set to confirm Pfizer's COVID-19 vaccine is safe and effective against the virus, according to documents released ahead of a crucial meeting on the vaccine this week. https://t.co/5jBIp1oeyC

— ABC News (@ABC) December 8, 2020