Cell Host & Microbe: Direct Comparison of Antibody Responses to Four SARS-CoV-2 Vaccines in Mongolia



Cell Host & Microbe

Direct Comparison of Antibody Responses to Four SARS-CoV-2 Vaccines in Mongolia


  • •Antibodies to four COVID-19 vaccines differed in an observational study in Mongolia
  • •Responses from high to low: Pfizer/BioNTech > AstraZeneca > Sputnik V > Sinopharm
  • •Breakthrough infections in June to early July 2021 were due mostly to the Alpha variant
  • •After breakthrough infection, high antibody levels are seen in all vaccine groups


Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V and Sinopharm. Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins reveal marked differences in vaccine responses, with low antibody levels and RBD-ACE2 blocking activity stimulated by the Sinopharm and Sputnik V vaccines in comparison to the AstraZeneca or Pfizer/BioNTech vaccines. The Alpha variant caused 97% of infections in Mongolia in June and early July 2021. Individuals who recover from SARS-CoV-2 infection after vaccination achieve high antibody titers in most cases. These data suggest that public health interventions such as vaccine boosting, potentially with more potent vaccine types, may be needed to control COVID-19 in Mongolia and worldwide.

Article Info

Publication History

Accepted: November 8, 2021Received in revised form: September 28, 2021Received: August 10, 2021

Publication stage

In Press, Accepted Manuscript

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