JAMA: Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes

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Original Investigation

March 24, 2022

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes

Maria C. Magnus, PhD1; Anne K. Örtqvist, MD, PhD2,3; Elisabeth Dahlqwist, PhD2; et alRickard Ljung, MD, PhD4,5; Fredrik Skår, MD6; Laura Oakley, PhD1,7; Ferenc Macsali, MD, PhD8,9; Björn Pasternak, MD, PhD2,10; Håkon K. Gjessing, PhD1,11; Siri E. Håberg, MD, PhD1; Olof Stephansson, MD, PhD2,12

Author AffiliationsArticle Information

JAMA. 2022;327(15):1469-1477. doi:10.1001/jama.2022.3271

Key Points

Questions  Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes?

Findings  In this population-based retrospective cohort study that included 157 521 deliveries in Sweden and Norway, SARS-CoV-2 vaccination during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with risk of preterm birth (adjusted hazard ratio [aHR], 0.98), stillbirth (aHR, 0.86), small for gestational age (adjusted odds ratio [aOR], 0.97), low Apgar score (aOR, 0.97), or neonatal care admission (aOR, 0.97).

Meaning  In this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy was not associated with an increased risk of adverse pregnancy outcomes.

Abstract

Importance  Data about the safety of vaccines against SARS-CoV-2 during pregnancy are limited.

Objective  To examine the risk of adverse pregnancy outcomes after vaccination against SARS-CoV-2 during pregnancy.
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Conclusions and Relevance  In this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with an increased risk of adverse pregnancy outcomes. The majority of the vaccinations were with mRNA vaccines during the second and third trimesters of pregnancy, which should be considered in interpreting the findings.
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Conclusions

In this population-based study conducted in Sweden and Norway, vaccination against SARS-CoV-2 during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with an increased risk of adverse pregnancy outcomes. The majority of the vaccinations were with mRNA vaccines during the second and third trimesters of pregnancy, which should be considered in interpreting the findings.


https://jamanetwork.com/journals/jama/fullarticle/2790608?guestAccessKey=fa6f2e29-76ea-4a3b-b826-c0af712986c9&utm_source=twitter&utm_medium=social_jama&utm_term=6805702141&utm_campaign=article_alert&linkId=161492291

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