Chise: Yes, your Covid-19 vaccine worked

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Chise: On childhood vaccines that require 3 doses a year

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Just a friendly reminder. If you test positive for SARS-COV-2 after being vaccinated and are experiencing mild symptoms or even no symptoms at all? Yes, your vaccine worked. Don’t let anyone tell you otherwise.

The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.

“The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.”

“The second thing to know about the COVID-19 vaccines is that they’re flame retardants, not impenetrable firewalls, when it comes to the coronavirus. Some vaccinated people are still getting infected, and a subset of these individuals is still getting sick

-and this is completely expected.” YES, post-vaccination infections indeed are known to occur after vaccination against other diseases, such as influenza and measles. Why? Because NO VACCINE IS 100% EFFECTIVE.

“Even the measles vaccine, which is incredibly effective, fails to protect about 3% of vaccinated individuals who are exposed to the virus. Jonas Salk’s polio vaccine-hailed a medical miracle- was 80% to 90% effective at preventing paralysis caused by the polio virus.”

So, for those saying the Polio vaccine is sterilizing? Try again. It took a DECADE for Polio to be eliminated in the U.S. and even longer for other parts of the world and guess what? It is still not fully eradicated. It’s still endemic in some countries. https://pubmed.ncbi.nlm.nih.gov/28718581/

Measles and Polio breakthrough infections aren’t just rare because the vaccines are so effective but also because those who are vaccinated rarely interact with infected people. Even with highly effective vaccines for COVID-19, breakthrough infections are likely to keep happening

because the virus is so widespread and we have highly transmissible variants like Omicron and it’s sub-lineages. For lighter reading on the subject I suggest:

https://smithsonianmag.com/science-nature/six-important-things-know-about-breakthrough-infections-180978408/
https://scientificamerican.com/article/breakthrough-infections-do-not-mean-covid-vaccines-are-failing/https://theatlantic.com/science/archive/2021/09/sterilizing-immunity-myth-covid-19-vaccines/620023/https://theatlantic.com/science/archiv

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With Omicron (+sublineages) are we likely to see more post-vaccination infections and reinfections? Yes. BUT at the same time we are seeing FEWER hospitalizations and deaths amongst vaccinated individuals. Also, the data on updated vaccines is promising.

Encouraging news! Moderna’s first bivalent booster vaccine candidate, mRNA-1273.211, demonstrated superior neutralizing titers compared to mRNA-1273 against ALL variants of concern INCLUDING Omicron! Superiority continued six months after administration. Let’s talk about that!

PLEASE NOTE. SUPERIORITY CONTINUED SIX MONTHS AFTER ADMINISTRATION, NOT ONLY SIX MONTHS. Just wanted to clarify that statement before comments started popping up. In addition, this study is in regards to NEUTRALIZING ANTIBODY RESPONSES ONLY. Let’s continue.

The manuscript is available as a preprint through Research Square: •https://assets.researchsquare.com/files/rs-1555201/v1_covered.pdf?c=1650045900

This phase 2/3 study evaluated the safety and immunogenicity of the bivalent vaccine candidate mRNA-1273.211 (equal mRNA amounts of ancestral SARS-CoV-2 and Beta variant spike proteins) as 50-μg (n=300) and 100-μg (n=595) first booster doses approximately 8.8-9.8 months AFTER

the mRNA-1273 primary series. The mRNA-1273.211 booster (50 and 100-μg) elicited HIGHER neutralizing antibody responses against the ancestral SARS-CoV-2 and the Beta variant than that after the second mRNA‐1273 dose.

Antibody responses after the 50-μg mRNA-1273.211 booster dose were also HIGHER than that after a 50-μg mRNA-1273 booster dose for the ancestral SARS-CoV-2, Beta, Omicron AND Delta variants (28 days after the booster dose) AND for the ancestral SARS-CoV-2, Beta AND Omicron

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(180 days after the booster dose), and the immunogenicity objectives were met. In addition, the safety and reactogenicity profile of the mRNA-1273.211 booster (50-μg) was comparable to mRNA-1273 (50-μg).

A booster dose of mRNA-1273.211 demonstrated superiority against the ancestral SARS-CoV-2 and the Beta, Delta and Omicron variants one month after the booster dose and superiority against the ancestral SARS-CoV-2, Beta and Omicron 6 months compared to the booster dose

mRNA-1273. There was a 2.20-fold (95% CI: 1.74, 2.79) and 2.15-fold (95% CI: 1.66, 2.78)increase in the neutralizing antibody titers against Omicron with the mRNA-1273.211 booster dose compared to the mRNA-1273 booster dose at 1 month and 6 months, respectively.

The results indicate that the bivalent booster vaccine candidate mRNA-1273.211 at the 50 µg dose level induced HIGHER antibody responses than the 50 µg mRNA-1273 booster, even when the variants were not included in the booster vaccine and that bivalent booster vaccines can induce

potent and durable antibody responses providing a new tool in response to emerging variants. Again, intial data for mRNA-1273.214, which combines mRNA-1273 with Moderna’s Omicron-specific booster candidate IS expected in the second quarter, and remains the lead candidate.

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The primary purpose of vaccines is to prevent disease. The vaccines do this. The vaccines don’t prevent transmission entirely but they do significantly reduce it. With a booster, VE against infection is approaching 70%. So this is entirely wrong. https://twitter.com/arthur_affect/

Sure, omicron causes some breakthrough and reinfection. But it also results in far fewer hospitalizations and deaths. Why is that? Vaccines.

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Post-vaccination infections typically cause mild to moderate symptoms, if one develops symptoms at all. Another benefit of the vaccines is that they likely shorten the length of illness for many individuals who do become infected.

Remember. Per Dr. Rasmussen: Vaccines work but not instantly. Polio elimination took years and that was with an extremely pro-vaccine public who couldn’t wait to not get Polio. Just because the vaccines aren’t working on your timetable doesn’t mean they don’t work.

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