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Fauci on AstraZeneca press release drama: “It was not necessary. If you look at it, the data really are quite good. But when they put it into the press release it wasn't completely accurate.”
— Eric Feigl-Ding (@DrEricDing) March 23, 2021
Most silly unforced error by @AstraZeneca when least needed. https://t.co/3LW9wpwHFc
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This is a highly unusual statement by the US National Institute of Allergy and Infectious Diseases (NIAID). It comes close to accusing Oxford/AZ of having wilfully misrepresented some results from their recent US vaccine trial. https://t.co/cj86TYdY7e
— Prof Francois Balloux (@BallouxFrancois) March 23, 2021
Remarkable but not surprising. The National Institutes for Health is taking a very bold step tonight. It didn't need to news release this, indicating they are confident something in the AZ vaccine trial is problematic. https://t.co/TcywHIW0AD
— Patrick Brauckmann 🕉️ (@vonbrauckmann) March 23, 2021
The statement by NIAID apparently concerned the choice of cut-off date used by AZ for their efficacy estimates (Feb 17). Hopefully, the efficacy estimates will remain largely unchanged after inclusion of the latest data.https://t.co/KCwh4Aw4fn
— Prof Francois Balloux (@BallouxFrancois) March 23, 2021
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THIS IS WILD—the NIH is expressing “concern” about information released by AstraZeneca on initial #COVID19 vaccine trial data. “AstraZeneca may have included outdated information from trial, which may have provided an incomplete view of the efficacy data”
— Eric Feigl-Ding (@DrEricDing) March 23, 2021
https://t.co/ken8zJSeRB pic.twitter.com/HQA0tdL9tg
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Yesterday morning:
— Kai Kupferschmidt (@kakape) March 23, 2021
great results from large trial of AZ‘s #covid19 vaccine
Yesterday evening:
DSMB „expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data“https://t.co/0MiLuaUwy8
As far as I can parse this:
— Kai Kupferschmidt (@kakape) March 23, 2021
Results yesterday were interim analysis based on data with cut-off point February 17.
More up to date data is coming in form of the primary analysis within 48 hours and should not look all that different…
Let’s wait and see…https://t.co/fAIhTpKM2L
Fauci: “It really is unfortunate that this happened. You know this is really what you call an unforced error, because the fact is, this is very likely a very good vaccine and this kind of thing does as you say do nothing, but really cast some doubt about the vaccines …"
— Kai Kupferschmidt (@kakape) March 23, 2021
Fauci just called me as well and clarified the concerns:
— Kai Kupferschmidt (@kakape) March 23, 2021
“It appears that they [AZ] may have been using the most favorable data, and the DSMB wanted to make sure that they corrected that…"
A few noteworthy reactions.
— Kai Kupferschmidt (@kakape) March 23, 2021
Here‘s @EricTopol first: https://t.co/NTcy25oWPl
And @ashishkjha: https://t.co/QGa2CmATEN
— Kai Kupferschmidt (@kakape) March 23, 2021
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weehingthong 