The Mount Sinai’s Icahn School of Medicine study.
COVID vaccine tied to fewer heart attacks, strokes among previously infected
February 21, 2023
COVID-19 vaccination is linked to fewer heart attacks, strokes, and other cardiovascular issues among previously infected adults, suggests a US study today in the Journal of the American College of Cardiology.
Researchers from Mount Sinai’s Icahn School of Medicine parsed data from the country’s largest SARS-CoV-2 dataset, the National COVID Cohort Collaborative, on adults infected with SARS-CoV-2 from March 2020 to February 2022. The team tracked patients for 6 months to determine any association between COVID-19 vaccination and major cardiac events (MACE) among previously infected patients.
Participants were considered fully vaccinated if they had received at least two doses of the Pfizer/BioNTech or Moderna mRNA COVID-19 vaccines or one dose of the Johnson and Johnson (J&J) version at least 14 days before infection. They were considered partially vaccinated if they received their first or second mRNA dose or one J&J dose within 14 days of infection.
Average age among the 1,934,294 participants was 45.2 years, and 81.3% were White. Among 195,136 participants, (10.1%) were fully vaccinated, 88.7% were unvaccinated, and 1.2% were partially vaccinated.
In a Mount Sinai news release, first author and MD/PhD candidate Joy Jiang said, “Given the magnitude of SARS-CoV-2 infection worldwide, we hope our findings could help improve vaccination rates, especially in individuals with coexisting conditions,” she said.
COVID-19 vaccination associated with fewer heart attacks, strokes, and other cardiovascular issues
Reviewed by Emily Henderson, B.Sc.Feb 20 2023
Analyzing the most extensive datasets in the United States, researchers from the Icahn School of Medicine at Mount Sinai have revealed that vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19.
The research letter, “Impact of Vaccination on Major Adverse Cardiovascular Events in Patients with COVID-19 Infection,” was published in the Journal of the American College of Cardiology on February 20.
It is the first study to examine both full and partial vaccination and the link to major adverse cardiac events (MACE) in the United States, confirming similar analyses performed previously using the Korean COVID-19 registry. Researchers used the National COVID Cohort Collaborative (N3C) database, the largest national comprehensive database on COVID-19. Since its inception in 2020, the N3C has continuously collected and harmonized data from electronic health records of institutions nationwide. Included in this study were 1,934,294 patients, 217,843 of whom received mRNA vaccine formulations by Pfizer-BioNTech or Moderna or viral vector technology by Johnson & Johnson. Cox proportional hazards, a statistical technique, was implemented to assess vaccination association with MACE.
We sought to clarify the impact of previous vaccination on cardiovascular events among people who develop COVID-19 and found that, particularly among those with comorbidities, such as previous MACE, type 2 diabetes, high cholesterol, liver disease, and obesity, there is an association with a lower risk of complications. While we cannot attribute causality, it is supportive evidence that vaccination may have beneficial effects on a variety of post-COVID-19 complications.”
Girish N. Nadkarni, MD, MPH, Senior Author, Irene and Dr. Arthur M. Fishberg Professor of Medicine at Icahn Mount Sinai, Director of The Charles Bronfman Institute of Personalized Medicine, and System Chief, Division of Data Driven and Digital Medicine (D3M), Department of Medicine
“To our surprise, even partial vaccination was associated with lower risk of adverse cardiovascular events,” said first study author Joy Jiang, an MD/Ph.D. candidate in the lab of Dr. Nadkarni. “Given the magnitude of SARS-CoV-2 infection worldwide, we hope our findings could help improve vaccination rates, especially in individuals with coexisting conditions.”
- Jiang J, Chan L, Kauffman J, et al. Impact of Vaccination on Major Adverse Cardiovascular Events in Patients With COVID-19 Infection. J Am Coll Cardiol. null2023, 0 (0) .https://doi.org/10.1016/j.jacc.2022.12.006