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📍2.6x HIGHER ANTIBODIES—New study of Belgian hospital workers found Moderna #COVID19 vaccine offered ~2.6x higher antibody levels vs 2 jabs of Pfizer. Possibly due to higher Moderna dose (100 mcg vs 30 mcg), or longer 4 vs 3 week interval between doses.🧵 https://t.co/vgCizKEM3X pic.twitter.com/Phr7ywi3j7
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
3) “The higher mRNA content in mRNA-1273 compared with BNT162b2 and the longer interval between priming and boosting for mRNA-12733 (4 weeks vs 3 weeks for BNT162b2) might explain this difference.”
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
5) Notably this Moderna>>Pfizer trend is seen across all age groups, whether elderly, middle age, or young adults under 35. It’s a pretty clear difference. pic.twitter.com/ItCBhGpjzc
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
7) So Moderna or Pfizer, which is better? Before Delta, it’s been a wash. But since July, when #DeltaVariant showed up, it seems Moderna has beaten Pfizer on efficacy against breakthroughs in the Mayo Clinic study. (And no, I don’t own any Moderna or Pfizer stock that I know) pic.twitter.com/djHGGocZJw
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
2) The big elephant in the room is what to do about booster shots for J&J – we know another shot boosts immunity, but still no recommendations yet. Frustrating for countless J&J jabbed folks out there. https://t.co/6fvqVdIRs7
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
10) That said, a 3rd booster shot is quite good — very high potential efficacy – keep in mind these are 3 shots vs 2 shots comparison, not versus no vaccine. So versus no vaccine it’ll be ever higher! https://t.co/KadYEwH9RG
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
No data on Moderna mixing. But Pfizer after AZ seems good so far.
— Eric Feigl-Ding (@DrEricDing) August 31, 2021
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weehingthong 