JAMA: Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19 A Randomized Clinical Trial

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Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19A Randomized Clinical Trial

Susanna Naggie, MD, MHS1,2; David R. Boulware, MD, MPH3; Christopher J. Lindsell, PhD4; et alThomas G. Stewart, PhD4; Nina Gentile, MD5; Sean Collins, MD, MSci4; Matthew William McCarthy, MD6; Dushyantha Jayaweera, MD7; Mario Castro, MD, MPH8; Mark Sulkowski, MD9; Kathleen McTigue, MD, MPH, MS10; Florence Thicklin11; G. Michael Felker, MD, MHS1,2; Adit A. Ginde, MD, MPH12; Carolyn T. Bramante, MD, MPH3; Alex J. Slandzicki, MD13; Ahab Gabriel, MD14; Nirav S. Shah, MD, MPH15; Leslie A. Lenert, MD, MS16; Sarah E. Dunsmore, PhD17; Stacey J. Adam, PhD18; Allison DeLong, BS1; George Hanna, MD19; April Remaly, BA1; Rhonda Wilder, MS1; Sybil Wilson, RN1; Elizabeth Shenkman, PhD20; Adrian F. Hernandez, MD, MHS1,2; for the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-6) Study Group and Investigators

Author Affiliations Article Information

JAMA. Published online October 21, 2022. doi:10.1001/jama.2022.18590

Key Points

Question  Does ivermectin, 400 μg/kg, daily for 3 days, compared with placebo, shorten symptom duration among adult (≥30 years) outpatients in the US with symptomatic mild to moderate COVID-19?

Findings  In this double-blinded, randomized, placebo-controlled platform trial conducted in the US during a period of Delta and Omicron variant predominance, and that included 1591 adult outpatients with COVID-19, the posterior probability of improvement in time to recovery in those treated with ivermectin vs placebo had a hazard ratio of 1.07, with a posterior probability of benefit of .91. This did not meet the prespecified threshold of posterior probability greater than .95.

Meaning  These findings do not support the use of ivermectin in outpatients with mild to moderate COVID-19.


https://jamanetwork.com/journals/jama/fullarticle/2797483?guestAccessKey=33c6d8a1-c8b1-4113-b86d-a01abbf52b36&utm_source=twitter&utm_medium=social_jama&utm_term=7960535910&utm_campaign=article_alert&linkId=186556262

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7 Chinese nationals charged in US for crimes related to China’s Operation Fox Hunt

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“Federal authorities in New York charged seven people Thursday, including five in the People’s Republic of #China, with a campaign of harassment against a Chinese national and his family living in the U.S., trying to force him to return home.” https://usnews.com/news/us/articles/2022-10-20/feds-7-charged-in-attempt-to-force-fugitive-back-to-china#:~:text=Federal%20authorities%20in%20New%20York,him%20to%20return%20to%20China.&text=Oct.%2020%2C%202022%2C%20at%206%3A00%20p.m.

They face charges including acting as agents of a foreign government, violations of the Travel Act and money laundering conspiracy.

The U.S. attorney’s office alleged the threats and harassment continued for years and were part of “Operation Fox Hunt,” characterized by the FBI as an illegal global effort by China to locate and repatriate alleged fugitives who flee to foreign countries.

According to an indictment, the defendants forced a relative of the unidentified man to travel from China to the U.S. to try to convince him to return. They also allegedly sent letters threatening “severe legal punishments” and sued the man and his son in New York, alleging the man had stolen money from his employer in China.

Quanzhong An, of Roslyn, New York, described by prosecutors as the primary U.S. liaison in the conspiracy, met repeatedly with the man in 2020, 2021 and 2022 seeking to persuade him to return to China, including telling him the lawsuit would be dropped if he did so, according to the indictment.

The indictment also charged An and his daughter, Guangyang An, also of Roslyn, with conspiracy to commit money laundering for allegedly enlisting dozens of third parties to transfer millions of dollars from China to the U.S. in smaller increments to avoid running afoul of U.S. money laundering laws.

The indictment also charged An and his daughter, Guangyang An, also of Roslyn, with conspiracy to commit money laundering for allegedly enlisting dozens of third parties to transfer millions of dollars from China to the U.S…

Michael Horn, an attorney representing Quanzhong An, said his client “was never working for the Chinese government,” and added, “we will spend the next few weeks attempting to understand why the U.S. attorney’s office has jumped to such an unjustified conclusion.”

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Young bus drivers in Singapore on their seemingly “uncle” job

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Kenya’s $3.8 Billion Chinese-Built Railway Shows Why Belt and Road Is Being Reworked

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The Great Equalizer: Irregular Warfare in the City (podcast)

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https://mwi.usma.edu/the-great-equalizer-irregular-warfare-in-the-city/

https://mwi.usma.edu/the-great-equalizer-irregular-warfare-in-the-city/?s=09

https://mwi.usma.edu/the-great-equalizer-irregular-warfare-in-the-city/

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CCP Congress & Xi Jinping: Most powerful leader since Mao? | China Tonight

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‘The student’s expression says it all’: School gives raw pork to students as award

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Ukraine War: the soldiers fighting Russia from beneath the trees #Bakhmut

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Hannah Yeoh: 18 already? Watch and forward

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What happened at the Chinese consulate?

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