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Cardiovascular Effects of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents

Version 1 : Received: 7 August 2022 / Approved: 8 August 2022 / Online: 8 August 2022 (10:40:23 CEST)
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A peer-reviewed article of this Preprint also exists.
Mansanguan, S.; Charunwatthana, P.; Piyaphanee, W.; Dechkhajorn, W.; Poolcharoen, A.; Mansanguan, C. Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents. Trop. Med. Infect. Dis. 2022, 7, 196. Mansanguan, S.; Charunwatthana, P.; Piyaphanee, W.; Dechkhajorn, W.; Poolcharoen, A.; Mansanguan, C. Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents. Trop. Med. Infect. Dis. 2022, 7, 196.
Journal reference: Trop. Med. Infect. Dis. 2022, 7, 196
DOI: 10.3390/tropicalmed7080196
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This study focuses on cardiovascular effects, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students from two schools aged 13–18 years who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms.We enrolled 314 participants; of these, 13 participants were lost to follow up, leaving 301 participants for analysis. The most common cardiovascular effects were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessments. Cardiovascular effects were found in 29.24% of patients, ranging from tachycardia, palpitation, and myopericarditis. Myopericarditis was confirmed in one patient after vaccination. Two patients had suspected pericarditis and four patients had suspected subclinical myocarditis. Conclusion: Cardiovascular effects in adolescents after BNT162b2 mRNA COVID-19 vaccination included tachycardia, palpitation, and myocarditis. The clinical presentation of myopericarditis after vaccination was usually mild, with all cases fully recovering within 14 days. Hence, adolescents receiving mRNA vaccines should be monitored for side effects. Clinical Trial Registration: NCT05288231
https://www.preprints.org/manuscript/202208.0151/v1
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Reuters
Fact Check-Study of Thai teenagers did not find one third experienced heart effects after COVID vaccination
A study of 301 teens in Thailand found mild and temporary heart rhythm changes after a second dose of the Pfizer-BioNTech COVID-19 vaccine among one in six teenagers, not one-third as social media posts claim. The study also saw possible signs of heart inflammation in just seven of those teens with rhythm changes and confirmed myocarditis in only one of the seven.
Social media users are circulating the study of post-vaccination heart effects in Thai teenagers with the claim that a third of participants experienced heart effects, and the suggestion that the results indicate a new danger level for children. These posts are missing context: the study’s authors concluded, “We found the risk of these symptoms to be not as low as reported elsewhere, but in all cases, symptoms were mild with full recovery within 14 days.”
A Twitter post shared more than 11,000 times (here) contains a link to the preprint study by Suyanee Mansanguan of Bhumibol Adulyadej Hospital in Bangkok and colleagues, with the comment, “BREAKING: A new study has found cardiovascular adverse effects in around a third of teens following Pfizer vaccination, and heart inflammation in one in 43, raising fresh concerns about the risks of vaccination for young people. This is beyond concerning.”
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Mansanguan and colleagues note in their draft study, released as a preprint on Aug. 8 (here), that they likely saw higher rates of heart rhythm disturbance and signs of inflammation than in other studies because they did tests that detected mild changes in participants with no symptoms who would not ordinarily have been screened.
The analysis included 301 people aged 13-18 recruited from two Bangkok schools before receiving their second dose of the Pfizer-BioNTech mRNA COVID-19 vaccine in November and December of 2021. The students were mostly male (67%) and none had “abnormal” symptoms after their first vaccine shot, the study notes.
Before receiving the second vaccine shot, each participant had a physical exam, a heart ultrasound called an echocardiogram, heart rhythm measurements by electrocardiogram (ECG or EKG) and blood tests to look for heart-related biomarkers including Troponin-T and CK-MB, both markers of damage to heart muscle. The exam and the tests were repeated on days 3 and 7 following the second vaccine shot, and on day 14 for some of the teenagers. The participants also kept symptom diaries throughout the study period and were able to contact or visit the study team doctors at any time to ask questions or discuss unusual symptoms.
Overall, 50 of the 301 students reported fever after the second vaccine shot and 35 reported headache, both common general side effects following COVID-19 vaccination.
Among cardiovascular effects detected only by ECG, 54 participants (18%, so roughly one in six, not one in three as social media rates) had rapid heartrate or abnormal heart rhythm. Of these, 39 had reported symptoms such as palpitations or chest pain. Fifteen reported no symptoms at all.
Among the participants with abnormal ECG, seven – all males — also had elevated biomarkers of heart muscle injury or inflammation. Of these seven, four had reported chest discomfort or pain, but three had no symptoms other than the elevated biomarkers. All seven also had normal heart function and no sign of reduced pumping ability that can signal heart failure.
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The Thai team confirmed one case of myocarditis (heart inflammation) in the 301 students — not one in 43 as suggested in social media posts.
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False. The study of teenagers in Thailand following a second COVID-19 vaccination found that 18% — not one third — experienced any detectable cardiac effect, and that 1 in 301, not 1 in 43, had confirmed myocarditis. A large proportion of purported abnormalities detected by testing were without symptoms, and 100% of the teens in the study fully recovered after 14 days, the authors reported.
This article was produced by the Reuters Fact Check team. Read more about our work to fact-check social media posts here .
Our Standards: The Thomson Reuters Trust Principles.
https://www.reuters.com/article/factcheck-heart-teens-vaccine-idUSL1N2ZT2B5
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Meta-owned Facebook and Twitter have been blocked in China since 2009, as part of a government crackdown against activists following deadly riots in Xinjiang province. China’s restriction of foreign media platforms and censorship of non-governmental material has been dubbed the Great Firewall of China. Meta’s messaging platform Whatsapp and its photo- and video-sharing app Instagram are also blocked. 18 Jan 2022
https://time.com/6139988/countries-where-twitter-facebook-tiktok-banned/
Twitter, Snapchat and TikTok, Messenger, Telegram, and Line, are also blocked.
Zoom is partially blocked.
LinkedIn is not available in China
The complete list:

https://www.saporedicina.com/english/list-of-blocked-websites-in-china/
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Associated PressWed 1 Mar 2023 00.37 GMT
Beijing – which itself blocks access to Facebook, Twitter and many others – hits out at ban on Chinese-owned software on US government devices
US government bans on Chinese-owned video sharing app TikTok reveal Washington’s own insecurities and are an abuse of state power, a Chinese foreign ministry spokesperson has said.
China, though, has itself long blocked a large list of foreign social media platforms and messaging apps, including YouTube, Twitter, Facebook and Instagram.
The US government “has been overstretching the concept of national security and abusing state power to suppress other countries’ companies”, Mao Ning said at a daily briefing on Tuesday. “How unsure of itself can the US, the world’s top superpower, be to fear a young person’s favourite app to such a degree?”
The White House is giving all federal agencies, in guidance issued Monday, 30 days to wipe TikTok off all government devices. The White House already did not allow TikTok on its devices.
TikTok is used by two-thirds of American teenagers, but there is concern in Washington that China could use its legal and regulatory powers to obtain private user data or to try to push misinformation or narratives favouring China.
Congress and more than half of US states have so-far banned TikTok from government-issued mobile devices.
Some have also moved to apply the ban to any app or website owned by ByteDance, the private Chinese company that owns TikTok and moved its headquarters to Singapore in 2020.
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The app will be removed from Canadian government issued phones on Tuesday.
The European Union’s executive branch said last week it has temporarily banned TikTok from phones used by employees as a cybersecurity measure.
TikTok has questioned the bans, saying it has not been given an opportunity to answer questions and governments were cutting themselves off from a platform loved by millions.
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Hadi predicts imminent collapse of Anwar’s govt
Published: Mar 1, 2023 10:04 AM
PAS president Abdul Hadi Awang has predicted that Anwar Ibrahim’s government will collapse soon.
Hadi shared his prediction during a dialogue organised by book publisher Yayasan Permata Ummah in Kuala Lumpur last night but was short on details.
He did not specify whether the cause of the collapse would come from within or without.
“People ask me when it will happen. That is my prediction. God willing, (it will) happen soon,” said Hadi (above).
Hadi’s cryptic remark came a few hours after he told the Dewan Rakyat that the opposition should not be blamed if the federal government collapses.
“(The government’s) roof is leaking. Their doors are wide open and their walls have holes,” Hadi told the Dewan Rakyat.
https://www.malaysiakini.com/news/656881
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Viki Male is Dr Victoria Male, a Senior Lecturer in Reproductive Immunology based in the Department of Metabolism, Digestion and Reproduction at Imperial College London.
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James Thorp MD: Vicki Are you aware that http://UK.Gov specifically states on their website that they DO NOT RECOMMEND the C19 “vaccines” in pregnancies & breastfeeding? The link is in our recent publication. I respect your opinions. As a follower of Christ I seek TRUTH at all cost. I am the <= 1% of humans that HAS and WILL publicly admit I am wrong and repent with an academic metanoia if I see data. I commit to being collegial & respectful if you debate me. I think this would be a terrific step forward. Why has NOBODY been willing to debate me over the last 3 years?
Viki Male: Hi James. That’s not true. The UK government offers and recommends getting vaccinated or boosted against COVID in pregnancy. Here’s the link for you…
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The Vigilant Fox: More Lethal Than Abortion Pills: Horrifying Miscarriage Rates With the COVID Injection In January of 2021, the New England Journal of Medicine came out with an article that stated that pregnant women who got the shot did not have a higher rate of spontaneous miscarriage. However, when you look at the data, they lumped women in their third trimester into the first-trimester group and assessed whether or not they had a first-trimester spontaneous miscarriage. When you take that cohort out, the rate of miscarriage was 82%, right in line with findings from the Pfizer documents. Dr. Elizabeth Mumper: “For a first-trimester woman to get this injection, they have more of a chance of having a miscarriage or stillbirth than if they were to actually take an abortifacient.”
Viki Male: Don’t forget that the miscarriage rate in V-safe was no higher than normal. The claim made here forgets to include participants in V-safe who were still pregnant. More information about the error here… 1/
And here are the miscarriage rates in V-safe (once there was enough follow up to determine them accurately). The miscarriage rate among those who have been vaccinated against COVID is the same as normal. 2/2
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Simone Gold: There has been a 4070% increase in miscarriages and stillbirths since the release of the experimental mRNA vaccines, according to VAERS data. Please retweet. Let’s save as many lives as possible.
Viki Male: It’s important to distinguish between an increase in *reports* and an increase in pregnancy loss. There’s no evidence for an increase in pregnancy loss (or any other pregnancy problem) following vaccination… 1/
https://docs.google.com/document/d/19FNXcmdI0MU6RPmvKYo_g9zEWPKl2-l760OX_8zww3E/edit
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Viki Male:
48,868 babies followed for first 120 days of life. Does being born after a #CovidVaccine booster in #pregnancy protect against hospitalisation for COVID?
Yes! With 53% effectiveness compared to two doses only. /1
Other important findings… Protection is greater when the booster dose is given later in pregnancy Protection wanes as babies get older, with no significant protection after 90 days, in this study. 2/
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Viki Male: The miscarriage rate following COVID vaccination in pregnant women is the same as normal – between 12.5 and 18.7%. Claims that it is higher than normal are circulating (again). They are based on the miscarriage rate after seeing a heartbeat on a scan. But we can’t apply this rate to all pregnancies.
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Eric Burnett, MD: Just so you know, this would mean there would be more miscarriages than actual pregnancies. This is dumb…
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Viki Male: #CovidVaccination in pregnancy protects #babies after birth. But what if you get vaccinated *after* your baby is born?
Canada: Test-negative case control. Vaccination of mothers after birth was 73% protective vs delta infection and 13% vs omicron in babies 1/
Protection against babies going to hospital with omicron was higher – 36% This effect is called cocooning and has been observed for other vaccines. Vaccinated parents are less likely to catch and transmit infections to their babies.
Nice work @canuckIDpharm !
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Viki Male: The miscarriage rate following COVID vaccination in pregnancy is the same as normal – between 12.5 and 18.7%. Claims that it is higher than normal are circulating. These are based on misconceptions that the miscarriage rate is lower than it actually is.
Deborah Cole: And as a woman, can I say that I am personally horrified that you would recommend that any woman take any experimental product during pregnancy!? I’ll pass on being your human guinea pig. Thank you very much.
Viki Male: As a woman, I was pleased to have the chance to protect myself and my babies by getting the vaccines my midwife recommended. There’s a very extensive evidence base supporting flu, COVID and whooping cough vaccination in pregnancy – nobody is a guinea pig.
Deborah Cole: “Babies”: You had multiple babies during COVID? That seems unlikely I have no beef with well-tested, tried & true vaccines. But mRNA is not a normal vax, it’s experimental Gene Therapy. Any woman who was instructed to take it during pregnancy unknowingly played Russian Roulette.
Viki Male: I had my kids before the pandemic, but I was still glad to have the vaccines that my midwife recommended at the time – particularly with respect to my eldest who was born in the 2014 whooping cough outbreak.
Elise Atkin: This is a shockingly bad reply to her tweet. You just sound like your grasping at straws. I believe the thread is about MRNA. Best you stay in track.
Deborah Cole: Oh well, that’s good enough for me! I guess I’ll just take your word for it then Actually, maybe not: I’m 4 kids wiser & know about DES, thalidomide, etc. No way you can tell me it’s safe to inject myself with mRNA while pregnant. I’ll wait & watch for a generation first…
Viki Male: I don’t expect anyone to take my word for anything. Links to the data so you can look for yourself are in the thread I was retweeting but here they are again for you.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00682-6/fulltext
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The vaccines do not pass through breast milk, but antibodies do — providing hope that breastfed babies might have some level of protection.
https://www.nature.com/articles/d41586-021-01680-x
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16 times. So far, so BIG.
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The Front Line COVID-19 Critical Care Alliance (FLCCC) is a group of physicians and former journalists formed in April 2020 that has advocated for various unapproved, dubious, and ineffective treatments (e.g. hydroxychloroquine, ivermectin, and other miscellaneous combinations of drugs and vitamins) for COVID-19.[1][2][3][4][5][6] The group is led by Paul E. Marik and Pierre Kory.[3] Both would later join conservative or right-wing groups promoting COVID-19 vaccine hesitancy and misinformation.
The World Health Organization, U.S. Food and Drug Administration, and European Medicines Agency advise against the use of ivermectin for COVID-19 outside of clinical trials, but the FLCCC has contended that ivermectin could reduce viral load and accelerate recovery in patients.[7][8][9]
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In November 2022, Pierre Kory and the FLCCC began marketing a cocktail of supplements and drugs (e.g. ivermectin and nitazoxanide) for other viruses, influenza and Respiratory syncytial virus (RSV). Like the FLCCC-advocated COVID treatments, the recommendations lacked credible supporting scientific evidence. The Washington Post estimated that this cocktail could cost over $500.[22]
https://en.wikipedia.org/wiki/Front_Line_COVID-19_Critical_Care_Alliance
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Published On: January 27, 2023
(Video)
Just-in-Case” treatment kit for COVID, RSV and Flu.
Being proactive before you become sick is the single best step to protecting yourself and your loved ones. Healthy habits, good food choices, regular exercise, and supplements support a strong immune system. It is also good practice to check and maintain vitamin D levels and to take daily probiotics.
Become familiar with the FLCCC protocols before you need to use them. We recommend you read both the protocols and the clinical companion guidelines to learn about our recommendations. The FLCCC has a prevention and two treatment protocols for COVID-19, RSV, and flu.
Here is what you need to have ready at home in your treatment kit for COVID-19, RSV, and flu viruses. Check each protocol and clinical companion for complete information the following items:
• Mouthwash with CPC and 1% povidone iodine nasal spray
• Vitamin D3, Vitamin C, and zinc
• Melatonin, quercetin, resveratrol or a flavonoid combo, and elderberry
• N-acetylcysteine (NAC), Nigella sativa, curcumin, and probiotics
• Aspirin, B vitamins, and Omega-3 supplements
• You can obtain prescriptions for ivermectin, nitazoxanide, and hydroxychloroquine from a telehealth provider.
https://covid19criticalcare.com/tools-and-guides/just-in-case-kit-for-covid-rsv-and-flu/
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https://www.washingtonpost.com/health/2023/02/26/ivermectin-use-covid-flu-rsv/
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Becker Hospital Review
Paige Twenter – yesterday
A group of physicians that promoted ivermectin as a COVID-19 medication, which was disregarded, is now touting the drug as a treatment for influenza and respiratory syncytial virus despite a lack of evidence, The Washington Post reported Feb. 26.
The physician group formed in 2020 as the Front Line COVID-19 Critical Care Alliance to help “prevent and treat COVID.” In a recent post, the FLCCC said masks make people sicker and social distancing is a myth. The group also says ivermectin can be used to treat COVID-19, flu and RSV as the CDC and other medical experts strongly disagree.
The FLCCC cites test tube studies for their treatment recommendations, but John Moore, PhD, a microbiology and immunology professor at Weill Cornell Medical College in New York City, pushed back on this connection.
“If you threw Coca-Cola into cell culture, you would see an antiviral effect,” Dr. Moore told the Post. “But you wouldn’t want to be squirting Coca-Cola up your nose against the flu and RSV.”
Multiple studies have shown ivermectin is not an effective treatment for COVID-19, and the World Health Organization agrees. A CDC spokesperson told the Post the drug is not a proven treatment for flu or RSV.
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